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p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.
This new discovery in relation to the molecular circuitry regulation the G1 cell cycle checkpoint provides a unique insight into why the new anti-cancer approach proposed using Cdc7 targeted anti-cancer therapies can act as powerful tumour killing agents but do not affect the normal cells of the body thereby circumventing the toxicity associated with conventional […]
Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment
Using immunohistochemistry and flow cytometry to define phases of the cell cycle, this study shows that a high proportion of acute myeloid leukaemia (AML) blasts obtained from trephine biopsies are cycling, whereas >95% of peripheral blood-derived blasts are arrested in G1 . Results obtained from bone marrow aspirates are more similar to those from blood […]
Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint
PURPOSE Cdc7 is a serine/threonine kinase which is responsible for the ‘firing’ of replication origins leading to initiation of DNA replication. Inhibition or depletion of Cdc7 in normal cells triggers a DNA origin activation checkpoint causing a reversible G1 arrest. Here we investigate Cdc7 as a novel therapeutic target in pancreatic cancer. EXPERIMENTAL DESIGN Cdc7 […]
Precision Medicine is hot topic at ASCO
CHICAGO: A precision medicine approach using a patient’s individual tumor biomarkers to determine the best treatment leads to significantly better outcomes, according to data being presented at this year’s American Society of Clinical Oncology (ASCO) meeting. A meta-analysis of 346 Phase I clinical trials involving more than 13,000 patients found that patients whose treatment […]
Cancer treatment untested in many patients with immune problems
Thousands of cancer patients could be spared chemotherapy every year following significant advances in personalised medicine, experts have said. Because of this, patients may find themselves stopping the pills before the first five years, resulting in risks not being lowered. Instead, targeted drugs created to bring the cancer under control can be selected – […]
Defining cancers based on genetic ‘fingerprint’ could help personalise treatment
“We’re starting to move from general treatments chosen on the basis of the tissue where the cancer starts and what the cancer looks like, to an era of molecular-designed therapy, targeting a tumour’s genetic fingerprint” – Professor Peter Johnson, Cancer Research UK Doctors are closer to personalising treatment for some cancers as genetic analysis of […]
Precision medicine can widen cancer care options, studies find
Using a patient’s individual tumor biomarkers to determine the best treatment can improve success rates, studies showed Saturday. Unlike chemotherapy and radiation therapy, targeted medicine allows for the preservation of healthy cells. This approach, especially immunotherapy, which boosts the immune system to destroy tumor cells — is revolutionizing oncology, according to the study released at […]
Targeted cancer care to spare thousands of patients chemotherapy
Precision medicine is about finding the right key for the lock, finding out what it is that is driving the tumour, what makes it tick. Prof Roy Herbst Thousands of cancer patients could be spared chemotherapy every year following significant advances in personalised medicine, experts have said. The “future of cancer treatment” is likely to […]
NHS should give all cancer patients personalised care
Life-changing personalised cancer treatments should be offered to all patients on the NHS as standard care and not be restricted to clinical trials, experts say. Results from an international study show that genetic testing of tumours can boost survival and avoid unnecessary treatments. Despite the evidence, British scientists fear that the NHS will lag […]
The personalisation of cancer treatments is leading to better outcomes for patients
Personalised cancer treatment, long talked of, is thus now becoming real. By detecting problems earlier and getting therapies right first time, it will save lives which might otherwise be lost. Better molecular understanding of the underlying processes of cancer, meanwhile, will extend the range of lives that medicine can aspire to save. There is still […]
‘Most exciting cancer treatment since chemotherapy’ could save patients using DNA tests
“Personalised medicine is a very, very different way of treating patients. It’s the most exciting thing since chemotherapy” R. Sharpe A revolutionary approach to treating cancer using DNA tests can shrink tumours at six times the rates of conventional medicine, major trials reveal today. Experts said the promise shown by “precision medicine” was “the […]
Precision medicine the theme at world’s biggest cancer conference
New era of targeted treatment that will extend survival rates detailed at American Society of Clinical Oncology meeting A new era of cancer treatment is beginning in which patients get drugs matched specifically to their tumour, according to scientists at the world’s biggest cancer conference in Chicago. Precision or personalised medicine, as it is […]